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Hematopoietic stem cells are tiny and few, but their descendants become the hundreds of millions of new red and white blood cells and platelets your body needs each day. How does your body care for its stem cells? What makes a stem cell feel at home? We are using recently developed methods to image intact bone marrow from lab mice. Our goal is to find and map stem cells where they live, what lives near them, and how things change when we change the chemical signals in the cell environment. We hope these studies will lead to a better understanding of the stem cell environment, and eventually, better outcomes for patients with blood cancers and other diseases.